United States securities and exchange commission logo

                         October 4, 2023

       Natalie Holles
       Chief Executive Officer
       Third Harmonic Bio, Inc.
       1700 Montgomery Street, Suite 210
       San Francisco, California 94111

                                                        Re: Third Harmonic Bio,
Statement on Form S-3
                                                            Filed October 2,
                                                            File No. 333-274823

       Dear Natalie Holles:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Tamika
Sheppard at 202-551-8346 with any questions.


                         Division of Corporation Finance

                         Office of Life Sciences
       cc:                                              Ryan Mitteness